Publications

Our publications

Publications

Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy
Woo CJ, Maier VK, Davey R, Brennan J, Li G, Brothers J, Schwartz B, Gordo S, Kasper A, Okamoto TR, Johansson HE, Mandefro B, Sareen D, Bialek P, Chau BN, Bhat B, Bullough D, Barsoum J. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1509-E1518. doi: 10.1073/pnas.1616521114. Epub 2017 Feb 13.

Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers
Subramanian RR, Wysk MA, Ogilvie KM, Bhat A, Kuang B, Rockel TD, Weber M, Uhlmann E, Krieg AM. Nucleic Acids Res. 2015 Oct 30;43(19):9123-32. doi: 10.1093/nar/gkv992. Epub 2015 Oct 7.

Genome-wide identification of polycomb-associated RNAs by RIP-seq
Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Borowsky M, Lee JT. Mol Cell. 2010 Dec 22;40(6):939-53. doi: 10.1016/j.molcel.2010.12.011.

Presentations

Epigenetic Upregulation of SMN2 Protein by Oligonucleotides Targeting Long non-coding RNA
Kristine M. Hussey, Roshni Davey, Emily Brand, David Knowlton, Brian Schwartz, Romesh R. Subramanian, Jim McSwiggen, Arthur Krieg, Jeff Keil, Herminio Cardona, Christine DiDonato, James Barsoum. Presented at the American Society for Human Genetics (ASHG), Oct. 22-26, 2013, Boston.

Epigenetic Upregulation of SMN2 Protein by Oligonucleotides Targeting Long non-coding RNA
Emily Brand, Roshni Davey, Caroline Woo, Brendan Connolly, David Knowlton, Brian Schwartz, Romesh Subramanian, Carolyn Chrzastowski, Jeff Keil, Christine DiDonato, James Barsoum. Presented at the Families of Spinal Muscular Atrophy (now Cure SMA), June 12-14, 2014, Maryland.

The Identification of Spinal Muscular Atrophy-associated Gene Expression and Antisense RNAs through Stranded RNA-seq
John Brothers II, Caroline Woo, Brian Schwartz, Jim Barsoum, and Andrey Sivachenko. Presented at Advances in Genome Biology & Technology (AGBT), February 26-28, 2015, Florida.

Targeting the GAA-Repeat Region with Oligonucleotides for the Treatment of Friedreich’s Ataxia
Fatih Ozsolak, Kamaljeet Sandhu, Susan Wood,Mark Wysk, Paula Lewis, David Bullough,James Barsoum. Presented at the International Ataxia Research Conference (ARC), March 25-28, 2015, Windsor, England.

A Novel Epigenetic Approach to Treat SMA
Caroline Woo, Roshni Davey, Hans Johannson, Arturo Orjalo, Peter Bialek, David Bullough, James Barsoum. Presented at the Cure SMA Researcher Conference, Friends & Family Session, June 17-20, 2015, Kansas City, MO.

Derepression of the SMN locus by inhibition of lncRNA-mediated PRC2 recruitment with a short steric blocking oligonucleotide
Caroline Woo, Verena Maier, Roshni Davey, James Brennan, Guangde Li, Brian Schwartz, Trevor Okamoto, Hans Johannson, Berhan Mandefro, Dhruv Sareen, Peter Bialek, David Bullough and James Barsoum. Presented at the Harvard Epigenetics Symposium, October 22, 2015, Boston.

Upcoming Events

May 22, 2017, 8:00 am

UBS Global Healthcare Conference

Presenter: Ronald Renaud, CEO

New York, NY

Past Events

March 30 , 2017

RNA & Oligonucleotide Therapeutics Conference

Presenter: Thomas McCauley, Ph.D., Chief Scientific Officer

Cold Spring Harbor, NY

March 28 - 29 , 2017

Cambridge Healthtech Institute’s Oligonucleotide and Peptide Therapeutics Conference

Presenter & Chairperson: Bal Bhat, Ph.D., Vice President of Chemistry

Cambridge, MA

March 6 - 8 , 2017

Cowen and Company 37th Annual Health Care Conference

Presenter: Ronald Renaud, CEO

Boston, MA

February 14 , 2017

BIO CEO & Investor Conference

Presenter: Ronald Renaud, CEO

Webcast – Replay available until May 15, 2017

New York, NY

February 14 , 2017

Genetic Rx

Presenter: Dr. Tom McCauley, CSO

Panel: Next Generation RNA Technologies

Harvard Medical School, Boston, MA

February 14 , 2017

Piper Jaffray Healthcare Conference

Presenter: Dr. Tom McCauley, CSO

Panel: Genomic 3.0 

New York, NY

February 14 , 2017

EuroTIDES

Presenter: Dr. Bal Bhat, VP Chemistry

Selective Endogenous mRNA Up-Regulation using Single Stranded Oligonucleotides

Berlin, Germany

February 14 , 2017

The 12th Annual Meeting of the Oligonucleotide Therapeutics Society

Sponsor and Participant

Montreal, QC, Canada

February 14 , 2017

FARA Energy Ball and Symposium

Sponsor and Participant

Tampa, FL

February 14 , 2017

The Allied Genetics Conference (TAGC) 2016

Sponsor

Orlando, FL

February 14 , 2017

JMP Securities Life Science Conference

Presenter: Ronald Renaud, CEO

New York, NY

February 14 , 2017

CureSMA Annual Conference

Sponsor and Poster Presentation, A novel epigenetic approach to treat SMA

Anaheim, CA

February 14 , 2017

IBC’s TIDES Oligonucleotide and Peptide Therapeutics

Long Beach, CA

February 14 , 2017

Fight SMA Annual Research Conference

Conference Sponsor and Participant

Alexandria, Virginia

February 14 , 2017

HealthTech: Oligonucleotide Therapeutics and Delivery Conference

Chairperson and Speaker, Bal Bhat, VP Chemistry, Novel Strategies for Endogenous mRNA Upregulation

Cambridge, MA

February 14 , 2017

Keystone Symposium: Chromatin and Epigenetics

Poster presentation, Dr. Caroline Woo, Senior Scientist, A gene upregulation technology that selectively activates genes by targeting PRC2-associated lncRNA.

Whistler, BC, Canada

February 14 , 2017

Cowen and Company 36th Annual Health Care Conference

Speaker: Ron Renaud, CEO

Marriot Copley Place, Boston

February 14 , 2017

The 18th Annual BIO CEO & Investor Conference

Speaker: Ron Renaud, CEO
Webcast

New York, NY

February 14 , 2017

Biotech Showcase 2016

Speaker: Ron Renaud, CEO

February 14 , 2017

International Ataxia Research Conference

Windsor, UK

February 14 , 2017

The 5th Annual Leerink Partners Healthcare Conference

Speaker: Ron Renaud, CEO

Webcast

New York, NY

February 14 , 2017

Long Noncoding RNAs: Marching Toward Mechanism (Keystone Symposium)

Keystone, CO

February 14 , 2017

Cowen & Company 35th Annual Healthcare Conference

San Francisco, CA

February 14 , 2017

JP Morgan Annual Healthcare Conference

San Francisco, CA

February 14 , 2017

ASHG

San Diego, CA

February 14 , 2017

OTS (Oligonucleotide Therapeutics Society)

San Diego, CA

February 14 , 2017

CSHL Conference

Long Island, NY

February 14 , 2017

EpiCongress

Boston, MA

February 14 , 2017

Post-Transcriptional Gene Regulation (Gordon Research Conference)

Newport, RI

February 14 , 2017

FSMA (Families of Spinal Muscular Atrophy)

Washington, DC

February 14 , 2017

American Society of Gene & Cell Therapy

Washington, DC

February 14 , 2017

TIDES

Providence, RI

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